Patients with neovascular AMD describe a sudden onset of decreased vision, metamorphopsia, and/or paracentral scotomas. Amsler grid self-testing by patients is highly effective for early detection of neovascular AMD. Clinical signs of CNV may include subretinal or intraretinal fluid (eg, CME), exudate and/or blood, a pigment ring or gray-green membrane, irregular elevation of the RPE or a PED, an RPE tear, and/or a sea-fan pattern of subretinal vessels.