The association between the C1QB rs291982*G genetic variant and schizophrenia obtained in our study may suggest the etiological significance of C1QB gene in schizophrenia in Armenian population. Furthermore, this finding may reflect implication of neurodegenerative component in schizophrenia [3]. Thus, Grewal et al (1999) demonstrated overexpression of C1QB in the areas undergoing neurodegeneration [33]. In addition, recent studies showing alterations in expression of C1QB gene in hippocampus and cerebral cortex in the animal models of Alzheimer's disease [33, 34], having some clinical features shared with schizophrenia such as neuron loss and cognitive impairment [1].