Aflibercept Aflibercept (also known as VEGF Trap) is a soluble protein that acts as a VEGF receptor decoy; it combines the ligand-binding elements of the extracellular domains of VEGFR1 and VEGFR2 fused to the constant region (Fc) of immunoglobulin G (IgG). Aflibercept binds both VEGF and placental-like growth factor and fully penetrates all retinal layers.