Also, the observed differences in the C1QB gene LD blocks between the patients with schizophrenia and control subjects may suggest that C1QB rs291982*G allele is a marker of a haplotype carrying "causative" variant located nearby on the first chromosome. In this context it is quite important to note that chromosomal region 1p36 carrying C1QB gene has already been associated with schizophrenia in two genome-wide linkage scans [14, 15].