20 of the worst epidemics and pandemics in historyFlu pandemic: 1889-1890. … American polio epidemic: 1916. … Spanish Flu: 1918-1920. … Asian Flu: 1957-1958. … AIDS pandemic and epidemic: 1981-present day. … H1N1 Swine Flu pandemic: 2009-2010. … West African Ebola epidemic: 2014-2016. … Zika Virus epidemic: 2015-present day.More items…•