On the other hand a look at the ROI for asthma, diabetes, and depression produced “mixed results.” “For example,” the report notes, “large-scale prevention programs directed at pre-diabetic patients (technically not DM programs) may cost more than they save, at least in the short run. On the other hand, diabetes DM programs directed at patients with active disease may produce savings and a positive ROI, although too few studies have been performed for these results to be conclusive.”