The nice thing about two column layout is that it makes it easy to make call-out boxes. These are the boxes with a different color background that you can use to highlight some information or note it as an aside. Highlight the text, go to Format->Paragraph Style, turn on the borders lines, and set the background to a different color. Bam, call out. Call outs in single column layouts are a little trickier, but still doable. We actually cheat and force part of our text to be two-column. Select a paragraph of text, and use Format->Columns to make that part of the document two columns. At the end of the first column, use Insert->Break->Column Break to ensure that the text wraps correctly, then set borders and shading as above. It requires a bit more manual text management, but it’s doable. You can even drag the column markers in the ruler at the top of the document to make them less than 50 / 50 on the page. If anyone finds a better way to do call-outs, let me know.