The typical afflictions of the planets must also be applied: Mars’ heat, Saturn’s coldness and vata, Rahu and Ketu hyper and hypo activity which is said to mimic Mars and Saturn. Planetary debilitation, weakness, affliction by natural or functional malefic (owners of 6th, 8th or 12th houses) can all play a role in afflicting a house and planet associated with the glands. For deep seated glandular debility affecting all aspects of life, we must also confirm the debility by sign, house, and planetary karakas from the rising sign, the sun and the moon.