As the main villain of what's arguably the greatest non-MCU superhero movie ever (we would have also accepted The Dark Knight or maybe Logan), Alfred Molina’s Otto Octavius doesn’t start out evil in 2004’s Spider-Man 2. In fact, the first time Tobey Maguire’s Peter Parker meets him is during an interview for a college paper. Peter has dinner with Otto and his wife, Rosalie, and Otto is pleasant, funny, and wise. He and Peter discuss the responsibility of smart, powerful men — the privilege of their gifts — just as Otto is planning to unveil his new fusion power reactor to the public for the first time. It will be the culmination of his entire life's work.