Central serous chorioretinopathy can easily be confused with AMD. Subretinal fluid may be seen in both conditions; however, eyes with CSC typically do not have associated subretinal hemorrhage unless secondary CNV has developed. The choroidal layer, which is best visualized using EDI-OCT, is typically thick in eyes with CSC compared to the typical thin choroidal layer in eyes with AMD. CSC is further characterized by geographic patches of RPE pigment mottling that may extend to the inferior periphery in a drainage or drippage-like gravitational configuration often referred to as “guttering.” These lesions can be visualized with fluorescein angiography or autofluorescence imaging.