People can be skeptical or distrusting of science for different reasons, whether it is about one specific finding from one discipline (for example, ‘The climate is not warming, but I believe in evolution’), or about science in general (‘Science is just one of many opinions’). We identified four major predictors of science acceptance and science skepticism: political ideology; religiosity; morality; and knowledge about science. These variables tend to intercorrelate – in some cases quite strongly – which means that they are potentially confounded. To illustrate, an observed relation between political conservatism and trust in science might in reality be caused by another variable, for example religiosity. When not measuring all constructs simultaneously, it is hard to properly assess what the predictive value of each of these is.