The frequencies of all studied genetic variants in the groups of schizophrenic patients and control subjects are shown in Table 1. C1QA rs292001 and C1QB rs913243 polymorphisms were almost equally represented in both groups (p > 0.05). By contrast, significant differences in the C1QB rs631090*C (22% vs 17%, OR = 1.4, 95%CI: 1.01-1.95, p nominal = 0.044) and rs291982*G (58% vs 46%, OR = 1.64, 95%CI: 1.26-2.13, p nominal = 0.0002) minor allele frequencies between schizophrenic patients and healthy subjects were found. After Bonferroni correction for the number of tested loci (n = 4), C1QB rs291982*G minor allele remained more frequent at significant level in schizophrenics compared to controls (p corrected = 0.0008). The overall distribution of C1QB rs291982 genotypes differed between the patients and controls (p corrected = 0.0004, 2 degrees of freedom, d.f.) due to the overrepresentation of rs291982 GG homozygotes among schizophrenics (36% vs 19%, p nominal = 2.4E-5, p corrected = 9.6E-5, 1 d.f., OR = 2.5, 95%Cl: 1.62-3.85). Further, the rs291982 GG genotype was associated with increased risk for schizophrenia when compared to both TG (p corrected = 0.0004) and TT (p corrected = 0.0016) genotypes. In contrast, the susceptibility to schizophrenia was almost equal in rs291982 TG and TT genotypes (p nominal = 0.82). These results suggest that the C1QB rs291982*G minor allele might be considered as a risk factor for schizophrenia in a homozygous status (GG genotype, recessive model), at least in Armenian population.