In this study the possible association of several polymorphisms of the complement C1Q component gene with susceptibility to schizophrenia was evaluated. No association of C1QA rs292001, C1QB rs913243 and rs631090 variants with disease was observed, whereas positive association of C1QB rs291982*G variant and namely GG genotype with schizophrenia was found. The results suggest that the C1QB rs291982*G minor allele might be in a homozygous status a risk factor for schizophrenia at least in Armenian population. Therefore, C1QB gene may be considered as a relevant candidate gene for susceptibility to schizophrenia.