The main contractual issues that need to be taken into account are: ownership of data; ownership of know-how products based on collaborations through which data is used; consideration for data sharing or know-how products based on use of the data, such as ownership in the outside organisation (if a company is concerned); right to use the know-how products; monetary compensation (such as royalties, licence fees, exit fees); period of use of the data; exclusivity of the data’s use; reach through royalties/licences; royalty rate and stacking; and the need to use other databases.