E-selectin (SELE, CD62E, ELAM-1), an 11-kD cell surface glycoprotein, is an adhesion molecule of the selectin family that mediates the interaction of circulating leukocytes with the vascular endothelium in various physiological and pathological settings [1]. Its corresponding gene SELE is located on human chromosome 1. Unique among other selectin family molecules, E-selectin typically is not detected in inactivated endothelial cells, but is rapidly synthesized in response to certain cytokines and other pro-inflammatory stimuli, making it a marker of the "activated" endothelial phenotype [2]. Leukocyte-endothelial interactions contribute to a variety of vascular disease processes, such as acute and chronic inflammation and atherosclerosis. Several soluble factors (e.g., cytokines, chemokines, and growth factors), as well as cell surface adhesion molecules, which are expressed by both endothelial cells and leukocytes, interact in a complex fashion to efficiently mediate leukocyte recruitment [3, 4].