Genetics and environmental factors both play very important roles in the establishment and development of essential hypertension. Genetics is considered to be of clinical importance by physicians and researchers in the pathogenesis, diagnosis, treatment and prevention of hypertension. With the advent of the human genome project and the international HapMap project, SNPs have become increasingly prominent in the study of both multifactorial and multi-genomic diseases. E-selectin, the product of the SELE gene, is closely associated with hypertension, coronary heart diseases and atherosclerosis, and thus appears to be a risk factor for these conditions. The gene encoding E-selectin is more strongly expressed in the plasma of hypertensive patients than in NT subjects [13, 14], and the level of E-selectin in sedentary, drug-treated hypertensives is significantly reduced after lifestyle intervention [15], confirming the association of E-selectin with hypertension. Moreover, Derzbach and colleagues found that the S128R variant of E-selectin is closely related to severe preeclampsia [16], and another study reported that the L554P variant increased the risk of BP in overweight people [7]. However, to our knowledge, the association of T1880C, C602A, T1559C E-selectin variants with essential hypertension has not been previously investigated.