Sometimes I tolerate them, sometimes I don't. Some brands I tolerate, some not. When I say don't tolerate what I mean is usually I get malaise, headaches, stuffed and runny sinuses, severe upper eyelid edema the following day. Culturelle was a disaaster. Custom Probiotics caps did nothing to control vaginal yeast infections. I find Renew Life Ultimate Flora the best for me. Maybe it's because the caps are enteric coated. I don't know. Been constipated since I was born. Rarely vomit or get diarrhea. But if I take antibiotics and don't take probios too I get a vaginal yeast infection. Sometimes I just get yeast infections even without taking antibiotics. Saccharomyces Bouillardii is another thing one may want to consider after Nystatin or fluconazole as those will kill your beneficial yeast, too.