Deadline Passed 05/17/2018. Deadline Unknown for 2019. OPHPR aims to support innovative research to improve the ability of CDC and its partners, especially state and local health departments, to effectively prepare for and respond to public health emergencies and disasters. Research topics were identified and prioritized through a systematic process, based on the needs of OPHPR. Topic areas in this solicitation are as follows (refer to the announcement for detailed explanations and requirements): Topic 1: Determining Requirements to Ensure Entities Have Effectively Inactivated Biological Select Agents and Regulated Nucleic Acids. Topic 2: Utility of the National Health Security Preparedness Index (NHSPI) for State and Local Public Health Preparedness Activities. Topic 3: Incident Management Systems (IMS) Promising Measures of Performance and Effectiveness. Topic 4: Evidence-Based Interventions to Mitigate Adverse Impacts on At-Risk Populations. Topic 5: Identifying Information Needs and Communication Channels for Reaching At-Risk Populations during Emergencies