... The thyroids of calves were enlarged 2 to 5 times their normal weight and the cows afficted with fluorosis showed evidence of hypo-thryoidism. The depression of the serum thyroxine (T4) and triiodothyronine (T3) correlated with the increase in urinary fluoride, with the number of red blood cells, with the hemoglobin, serum cholesterol, calcium, glucose and albumin. Fluoride also decreased the serum cholesterol at a lower level of significance (P <.06).