Also referred to as Botulinum Toxin Type A, Botox was first approved by the U.S. Food and Drug Administration (FDA) in 1989 to treat two muscle disorders of the eye. In 2000, the use of this prescription drug was expanded to cover muscle spasms in other areas. Two years later, the FDA approved the use of Botox to treat deep lines and wrinkling between the eyes. Botox can cause certain side effects that may include headaches, allergic reactions, bruising, redness and bleeding at the site of the injection or nausea and vomiting.