We previously reported a decrease in the PGC-1α/TFAM mitochondrial biogenesis pathway in placenta of mothers with diabetes (Jiang et al. 2017). Treating human placental explants with resistin resulted in a maximal decrease in PGC-1α protein abundance at 100 ng/ml (Fig. 4a) accompanied by a significant decrease in mitochondrial DNA copy number (Fig. 4b), demonstrating the capacity of resistin to regulate placental mitochondrial biogenesis.