Our lab investigates neural dynamics during active behavior and during off-line states, such as sleep, using a combination of computational modeling, signal processing techniques, and both invasive and non-invasive techniques for recording neural activity. The basic science knowledge gathered from these investigations is leveraged to understand how memories are instantiated in the brain, to gain insight into how learning occurs during brain machine interface (BMI) tasks, to improve BMI algorithms, and to develop the framework for stimulation and pharmacological therapies for diseases, especially those marked by abnormal neural dynamics during sleep (e.g., post-traumatic sleep disorder (PTSD) and Parkinson’s disease).