“Except in cases of accidental or occupational exposures, most exposures to chemicals are at “very low doses.” Most chemical safety studies look at the toxic effects of higher doses of chemicals and then assume decreasing toxicity with lower doses. Yet substances that disrupt the body’s own hormones — known as endocrine-disrupting compounds (EDCs)—can exert important biological effects at low doses – including those at which they are found in the everyday environment. These effects are often qualitatively different from those found in traditional toxicology experiments. Low-dose effects are especially likely in developing tissues, during the formative periods when even minuscule levels of naturally occurring hormones determine the normal course of development.[1] EDC effects are often strongest at low doses at developmental stages when the complex hormonal regulation has not yet been established.[2]