At 77, he faces questions of whether he could serve two full terms. His life has seen tragedy — Neilia and their baby daughter would die in a car crash a few weeks after he won his first Senate race, and his eldest son, Beau, died of brain cancer in 2015. Biden, who married his current wife, Jill, in 1977, once thought he was heading into retirement and that Beau — whom he has referred to as Joe 2.0 — would be the one to realize the goal of the presidency, not him.