text: 次黃嘌呤-鳥嘌呤磷酸核苷轉移酶為人體內一個轉譯自"HPRT1"基因的酵素HGPRT為一種轉移酶，可以催化將次黃嘌呤轉換為肌苷酸，也可將鳥嘌呤的反應轉為單磷酸鳥苷。這兩個反應都是將PRPP的5-磷酸核苷轉移至嘌呤上。HGPRT在核苷酸再利用合成途徑中扮演重要角色。功能.HGPRT催化下列反應：HGPRTase functions primarily to salvage purines from degraded DNA to reintroduce into purine synthetic pathways. In this role, it catalyzes the reaction between guanine and phosphoribosyl pyrophosphate (PRPP) to form GMP, or between hypoxanthine and phosphoribosyl pyrophosphate (PRPP) to form inosine monophosphate.Substrates and inhibitors.Comparative homology modelling of this enzyme in "" suggest that among all of the computationally screened compounds, , 1,3-dinitroadamantane, acyclovir and analogs of acyclovir had higher binding affinities than the real substrate (guanosine monophosphate).疾病中的角色.此基因的突變往往導致高尿酸血癥：The in silico and in-vitro correlation of these compounds were test in Leishmania HGPRT and validates the result.Hybridomas.s are immortal (immune to ), HGPRT+ cells that result from fusion of mortal, HGPRT+ plasma cells and immortal, HGPRT− myeloma cells. They are created to produce monoclonal antibodies in biotechnology. inhibits de novo synthesis of nucleic acids, killing myeloma cells that cannot switch over to the salvage pathway, due to lack of HRPT1. The plasma cells in the culture eventually die from senesence, leaving pure hybridoma cells.
metadata.dataset: erhwenkuo/wikipedia-zhtw
metadata.title: 次黃嘌呤-鳥嘌呤磷酸核苷轉移酶
metadata.url: https://zh.wikipedia.org/wiki?curid=4791831