answers: intracellular
context: the GTP–alpha complex. Hormone receptors can behave as transcription factors by interacting directly with DNA or by cross-talking with signaling pathways. This process is mediated through co-regulators. In the absence of ligand, receptor molecules bind corepressors to repress gene expression, compacting chromatin through histone deacetylatase. When a ligand is present, nuclear receptors undergo a conformational change to recruit various coactivators. These molecules work to remodel chromatin. Hormone receptors have highly specific motifs that can interact with coregulator complexes. This is the mechanism through which receptors can induce regulation of gene expression depending on both the extracellular environment and the immediate </s> cytoplasm and are referred to as intracellular or nuclear receptors, such as testosterone. Upon hormone binding, the receptor can initiate multiple signaling pathways, which ultimately leads to changes in the behavior of the target cells. Hormonal therapy and hormone receptors play a very large part in breast cancer treatment (therapy is not limited to only breast cancer). By influencing the hormones, the cells' growth can be changed along with its function. These hormones can cause cancer to not survive in the human body. Hormone receptor proteins bind to a hormone as a result of an accumulation of weak interactions. Because </s> may not undergo an enzyme-mediated alteration such as reduction, hydroxylation, or aromatization. Then the steroid binds to a specific steroid hormone receptor, also known as a nuclear receptor, which is a large metalloprotein. Upon steroid binding, many kinds of steroid receptors dimerize: two receptor subunits join together to form one functional DNA-binding unit that can enter the cell nucleus. Once in the nucleus, the steroid-receptor ligand complex binds to specific DNA sequences and induces transcription of its target genes. Because non-genomic pathways include any mechanism that is not a genomic effect, there are various non-genomic pathways. However, all of these
question: which type of hormone receptor plasma membrane bound or intracellular