-- Database schema
| Classification : GeneID [ TEXT ] primary_key , Localization [ TEXT ] | Genes : GeneID [ TEXT ] Genes.GeneID = Classification.GeneID , Essential [ TEXT ] , Class [ TEXT ] , Complex [ TEXT ] , Phenotype [ TEXT ] , Motif [ TEXT ] , Chromosome [ INTEGER ] , Function [ TEXT ] , Localization [ TEXT ] | Interactions : GeneID1 [ TEXT ] Interactions.GeneID1 = Classification.GeneID , GeneID2 [ TEXT ] Interactions.GeneID2 = Classification.GeneID , Type [ TEXT ] , Expression_Corr [ REAL ] |
-- -- Among the genes with nucleic acid metabolism defects, how many of them can be found in the vacuole?

SELECT COUNT(T1.GeneID) FROM Genes AS T1 INNER JOIN Classification AS T2 ON T1.GeneID = T2.GeneID WHERE T2.Localization = 'vacuole' AND T1.Phenotype = 'Nucleic acid metabolism defects';