Characterization of the Coronary Vascular Capacitance, Resistance, and Flow in Endocardium and Epicardium Based on a Nonlinear Dynamic Analog Model
An electrical analog model consisting of capacitors, diodes, linear, and nonlinear resistors was used to characterize the coronary pressure-flow relationships from the arterial side of the coronary circulation. Based on this analog model, an identifiable system was formulated whereby the coronary vascular capacitance and resistance in the endocardial and epicardial layer of the heart were estimated. This was done by solving a constrained least-squares problem using a nonlinear programming technique. Experimental data were obtained from 28 animal studies using swine with an artificially induced coronary stenosis. The analog model showed a very consistent representation of the coronary hemodynamics. The model also generated accurate estimates of the endocardial to epicardial blood flow ratios compared to those independently measured by the radioactive microsphere technique. The model-predicted epicardial capacitance had a mean of 4.2 ×10-3 mI/mmHg per 100 g tissue; while the endocardial capacitance was negligible in most cases. The result indicated that, in the stenosed coronary circulation of swine, capacitive flow contributes 20 percent in root-mean-square value to the total flow activity in epicardium; while flow in the endocardium is dominated by a resistive, vascular waterfall effect.