Synthesis of novel antofine and Cryptopleurine analogues
Antofine and Cryptopleurine, natural products belong to the phenanthroindolizidine and phenanthroquinolizidine group of alkaloids, have attracted much attention because of their extremely potent inhibition of cancer cell growth. In this paper, seven analogues with different substituents on phenanthrene ring were designed and synthesized, the chemical structures of these derivatives were characterized by MS and 1H-NMR.