Uniform CR bound: implementation issues and applications
The authors apply a uniform Cramer-Rao (CR) bound (A.O. Hero, 1992) to study the bias-variance trade-offs in single photon emission computed tomography (SPECT) image reconstruction. The uniform CR bound is used to specify achievable and unachievable regions in the bias-variance trade-off plane. The image reconstruction algorithms considered here are: 1) space alternating generalized EM and 2) penalized weighted least-squares.<<ETX>>