Statistical methods for analyzing gene expression data for cancer research.
Microarray technology allows for the simultaneous profiling of the expression levels of tens of thousands of genes, potentially whole genomes (DeRisi et al. 1997; Lipshutz et al. 1999; Shalon et al. 1996). This unique power has opened the way for new experimental designs that explore the transcriptional profile of cancer and other complex diseases (Alon et al. 1999; Golub et al. 1999; Perou et al. 1999; Schummer et al. 1999; Alizadeh et al. 2000; Bittner et al. 2000; Perou et al. 2000; Ross et al. 2000).