A novel high-sensitivity cardiac multi-biomarkers detecting system based on microfluidic chip and GMR sensor
Giant magnetoresistance (GMR) is a quantum mechanical magnetoresistance effect observed in thin-film structures composed of alternating ferromagnetic and non-magnetic conductive layers. Today GMR has been used in various fields including detecting DNA hybridization and pathogenic microorganism[1], screening diagnostic biomarkers[2], detecting HBV genotypes[3], and so on. NT-proBNP is an established risk factor in patients with heart failure or coronary disease. cTnI is considered the standard biomarker for acute myocardial infarction(AMI). The combined detection of NT-proBNP and cTnI could improve the sensitivity and specificity in clinical diagnosis of myocardial injury.