Extraction of the optic disk boundary in digital fundus images
The methods of active contours ("snakes") and level sets were applied to images of the retina in order to locate the outer boundary of the optic disk. A gradient-vector-flow based active contour was used as it performed well over a large range of initial conditions. Images were pre-processed to lessen the influence of blood vessels on boundary detection. Both active contours and level set methods accurately located the correct boundary; level set methods were computationally more intensive.