On Spatio-Temporal Dependency Changes in Epileptic Intracranial EEG: A Statistical Assessment
Pathological manifestations of epilepsy are generally associated with a set of clinical events that possess both spatial and temporal patterns. In this paper, based on a similar hypothesis, we study the evolution of epileptic seizures by analyzing temporal changes in the spatial bindings between various cortical structures. We propose to apply the Mantel statistics to quantitatively analyze the temporal changes in spatial-correlation matrices. The Mantel test is applied to 6 complex partial seizures of an epileptic patient. We show that, in 5 of the 6 instances, the spatial structures undergo significant connectivity changes in the 2 hours time-interval prior to the occurrence of a seizure.