Notice of RetractionA Comparative Investigation of the Nitrosodimethylamine Formation from the Nitrosation of Dimethylamine and Trimethylamine by Nitrite under the Neutral Condition
The nitrosation reactions of dimethylamine (DMA) and trimethylamine (TMA) by nitrite to form carcinogenic nitrosodimethylamine (NDMA) were studied under the neutral condition. A comparative investigation of the amounts of NDMA formation from the nitrosation reaction of amines (DMA and TMA) by nitrite at various ratios of amine and nitrite in phosphate salt buffer (pH=6.4) at elevated temperature (90°C) was made. The results showed that, as varying the concentration of amine, the yields of NDMA from DMA are considerably higher than those from TMA when the ratio of amine to NO2- is in a range of 1:1 to 10:1, whereas the amounts of NDMA produced from TMA are obviously more than those from TMA when the ratio grows to 50:1 or more. Differently, as varying the concentration of nitrite, the amounts of NDMA formation from DMA are always more than from TMA when the ratio of nitrite to amine is in the range of 1:1 to 150:1.