An Intrinsic Coordinate System of the Developing Human Brain
Magnetic resonance imaging of newborn infants with gestational age ranging from 24 to 40 weeks indicates majordevelopmental changes in the human brain over this time period [1]. Assessment of normal and abnormal anatomicalvariability requires a coordinate system enabling inter-subjectcomparison [2,3,4]. We present a method for identifyingan intrinsic coordinate system of the developing brain by applying a minimum entropy criterion to determine afﬁnetransformations to bring a group of subject scans into alignment.