Preparation, Sustained-Release and Transdermal Penetration Properties of Drug-Loaded Hollow Fibers
Acyclovir-loaded PAN hollow fibers were prepared with dry-wet spinning processes. The co- blendine method was employed to prepare the spinning liquid. The prepared hollow fibers had a diameter 01 300 mum. The drug content in the hollow fibers is lower than that in the spinning liquid, 20.28% of the drug was lost during the spinning processes. SIn vitro dissolution tests indicated the obvious initial burst effect. Permeability test results illustrated that the permeation of acyclovir is limited by the skin.