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{"sentences": [["Optochiasmatic", "and", "peripheral", "neuropathy", "due", "to", "ethambutol", "overtreatment", "."]], "ner": [[[2, 3, "Disease"], [6, 6, "Chemical"]]]}
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{"sentences": [["We", "characterize", "the", "clinical", ",", "neurophysiological", ",", "and", "neuroimaging", "findings", "in", "a", "72-year", "-", "old", "man", "who", "developed", "visual", "loss", "and", "paresthesias", "after", "11", "weeks", "of", "exposure", "to", "a", "supratherapeutic", "dose", "of", "ethambutol", "."]], "ner": [[[18, 19, "Disease"], [21, 21, "Disease"], [32, 32, "Chemical"]]]}
{"sentences": [["This", "case", "demonstrates", "the", "selective", "vulnerability", "of", "the", "anterior", "visual", "pathways", "and", "peripheral", "nerves", "to", "ethambutol", "toxicity", "."]], "ner": [[[15, 16, "Chemical"]]]}
{"sentences": [["Testosterone", "ameliorates"]], "ner": [[[0, 0, "Chemical"]]]}
{"sentences": [["streptozotocin", "-induced"]], "ner": [[[0, 0, "Chemical"]]]}
{"sentences": [["memory", "impairment", "in", "male", "rats", "."]], "ner": [[[0, 1, "Disease"]]]}
{"sentences": [["AIM", ":", "To", "study", "the", "effects", "of", "testosterone", "on", "streptozotocin"]], "ner": [[[7, 7, "Chemical"], [9, 9, "Chemical"]]]}
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{"sentences": [["memory", "impairment", "in", "male", "rats", "."]], "ner": [[[0, 1, "Disease"]]]}
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{"sentences": [["Testosterone"]], "ner": [[[0, 0, "Chemical"]]]}
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{"sentences": [["STZ", "administration", "and", "castration", "markedly", "decreased", "both", "STL1", "(", "the", "short", "memory", ")", "and", "STL2", "(", "the", "long", "memory", ")", "in", "passive", "avoidance", "tests", "."]], "ner": [[[0, 0, "Chemical"]]]}
{"sentences": [["Testosterone", "replacement", "almost", "restored", "the", "STL1", "and", "STL2", "in", "castrated", "rats", ",", "and", "significantly", "prolonged", "the", "STL1", "and", "STL2", "in", "STZ", "-treated", "rats", "."]], "ner": [[[0, 0, "Chemical"], [20, 20, "Chemical"]]]}
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{"sentences": [["-induced", "seizures", "."]], "ner": [[[1, 1, "Disease"]]]}
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{"sentences": [["It", "is", "widely", "used", "in", "folk", "medicine", "to", "treat", "skin", "diseases", "in", "both", "humans", "and", "animals", "as", "well", "as", "the", "seed", "decoction", "has", "been", "used", "to", "treat", "diarrheas", "and", "inflammatory", "diseases", "."]], "ner": [[[9, 10, "Disease"], [27, 27, "Disease"], [29, 30, "Disease"]]]}
{"sentences": [["However", ",", "there", "is", "no", "research", "on", "GFC", "effects", "in", "the", "central", "nervous", "system", "of", "rodents", "."]], "ner": [[[7, 7, "Chemical"]]]}
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{"sentences": [["In", "conclusion", ",", "our", "data", "suggest", "that", "GFC", "may", "influence", "in", "epileptogenesis", "and", "promote", "anticonvulsant", "actions", "in", "pilocarpine", "model", "by", "modulating", "the", "GABA", "and", "glutamate", "contents", "and", "of", "AChE", "activity", "in", "seized", "mice", "hippocampus", "."]], "ner": [[[7, 7, "Chemical"], [17, 17, "Chemical"], [22, 22, "Chemical"], [24, 24, "Chemical"]]]}
{"sentences": [["This", "compound", "may", "be", "useful", "to", "produce", "neuronal", "protection", "and", "it", "can", "be", "considered", "as", "an", "anticonvulsant", "agent", "."]], "ner": [[]]}
{"sentences": [["Standard", "operating", "procedures", "for", "antibiotic", "therapy", "and", "the", "occurrence", "of", "acute", "kidney", "injury", ":", "a", "prospective", ",", "clinical", ",", "non", "-", "interventional", ",", "observational", "study", "."]], "ner": [[[10, 12, "Disease"]]]}
{"sentences": [["INTRODUCTION", ":"]], "ner": [[]]}
{"sentences": [["Acute", "kidney", "injury"]], "ner": [[[0, 2, "Disease"]]]}
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{"sentences": [["It", "increases", "mortality", ",", "hospital", "length", "of", "stay", ",", "and", "costs", "."]], "ner": [[]]}
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{"sentences": [["Data", "collection", "was", "performed", "over", "a", "total", "of", "170", "days", "in", "three", "ICUs", "at", "Charite", "-", "Universitaetsmedizin", "Berlin", "."]], "ner": [[]]}
{"sentences": [["A", "total", "of", "675", "patients", "were", "included", ";", "163", "of", "these", "had", "therapy", "with", "vancomycin", ",", "gentamicin", ",", "or", "tobramycin", ";", "were", ">", "18", "years", ";", "and", "treated", "in", "the", "ICU", "for", ">", "24", "hours", "."]], "ner": [[[14, 14, "Chemical"], [16, 16, "Chemical"], [19, 19, "Chemical"]]]}
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{"sentences": [["AKI", "was", "defined", "according", "to", "RIFLE", "criteria", "."]], "ner": [[[0, 0, "Disease"]]]}
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{"sentences": [["Basic", "characteristics", "were", "comparable", ",", "except", "an", "increased", "rate", "of", "soft", "tissue", "infections", "in", "LAG", "."]], "ner": [[[12, 12, "Disease"]]]}
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{"sentences": [["TRIAL", "REGISTRATION", ":"]], "ner": [[]]}
{"sentences": [["Current", "Controlled", "Trials", "ISRCTN54598675", "."]], "ner": [[]]}
{"sentences": [["Registered", "17", "August", "2007", "."]], "ner": [[]]}
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{"sentences": [["A", "46-year", "old", "man", "with", "a", "chronic", "hepatitis", "C", "virus", "infection", "received", "triple", "therapy", "with", "ribavirin", ",", "pegylated", "interferon", "and", "telaprevir", "."]], "ner": [[[7, 10, "Disease"], [15, 15, "Chemical"], [17, 18, "Chemical"], [20, 20, "Chemical"]]]}
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{"sentences": [["Telaprevir", "was", "considered", "the", "probable", "causative", "agent", "of", "an", "interaction", "with", "simvastatin", "according", "to", "the", "Drug", "Interaction", "Probability", "Scale", "."]], "ner": [[[0, 0, "Chemical"], [11, 11, "Chemical"]]]}
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{"sentences": [["(", "200", "mg", "kg-1", ")", "."]], "ner": [[]]}
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{"sentences": [["Blepharoconjunctivitis", ",", "subjective", "complaints", "of", "dry", "eyes", ",", "blurred", "vision", ",", "contact", "lens", "intolerance", ",", "and", "photodermatitis", "are", "reversible", "side", "effects", "."]], "ner": [[[0, 0, "Disease"], [5, 6, "Disease"], [8, 9, "Disease"], [16, 16, "Disease"]]]}
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{"sentences": [["Chloroacetaldehyde", "as", "a", "sulfhydryl", "reagent", ":", "the", "role", "of", "critical", "thiol", "groups", "in", "ifosfamide", "nephropathy", "."]], "ner": [[[0, 0, "Chemical"], [3, 3, "Chemical"], [10, 10, "Chemical"], [13, 14, "Chemical"]]]}
{"sentences": [["Chloroacetaldehyde"]], "ner": [[[0, 0, "Chemical"]]]}
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{"sentences": [["Depletion", "of", "sulfhydryl"]], "ner": [[[2, 2, "Chemical"]]]}
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{"sentences": [["In", "this", "work", "the", "effect", "of", "CAA", "on", "human", "proximal", "tubule", "cells", "in", "primary", "culture", "(", "hRPTEC", ")", "was", "investigated", "."]], "ner": [[[6, 6, "Chemical"]]]}
{"sentences": [["Toxicity", "of", "CAA", "was", "determined", "by", "protein", "content", ",", "cell", "number", ",", "LDH", "release", ",", "trypan", "blue", "exclusion", "assay", "and", "caspase-3", "activity", "."]], "ner": [[[0, 0, "Disease"], [2, 2, "Chemical"], [15, 16, "Chemical"]]]}
{"sentences": [["Free", "thiols", "were", "measured", "by", "the", "method", "of", "Ellman", "."]], "ner": [[[1, 1, "Chemical"]]]}
{"sentences": [["CAA", "reduced", "hRPTEC", "cell", "number", "and", "protein", ",", "induced", "a", "loss", "in", "free", "intracellular", "thiols", "and", "an", "increase", "in", "necrosis", "markers", "."]], "ner": [[[0, 0, "Chemical"], [14, 14, "Chemical"], [19, 19, "Disease"]]]}
{"sentences": [["CAA", "but", "not", "acrolein", "inhibited", "the", "cysteine", "proteases", "caspase-3", ",", "caspase-8", "and", "cathepsin", "B.", "Caspase", "activation", "by", "cisplatin", "was", "inhibited", "by", "CAA", "."]], "ner": [[[0, 0, "Chemical"], [3, 3, "Chemical"], [6, 6, "Chemical"], [17, 17, "Chemical"], [21, 21, "Chemical"]]]}
{"sentences": [["In", "cells", "stained", "with", "fluorescent", "dyes", "targeting", "lysosomes", ",", "CAA", "induced", "an", "increase", "in", "lysosomal", "size", "and", "lysosomal", "leakage", "."]], "ner": [[[9, 9, "Chemical"]]]}
{"sentences": [["The", "effects", "of", "CAA", "on", "cysteine", "protease", "activities", "and", "thiols", "could", "be", "reproduced", "in", "cell", "lysate", "."]], "ner": [[[3, 3, "Chemical"], [5, 5, "Chemical"], [9, 9, "Chemical"]]]}
{"sentences": [["Acidification", ",", "which", "slowed", "the", "reaction", "of", "CAA", "with", "thiol", "donors", ",", "could", "also", "attenuate", "effects", "of", "CAA", "on", "necrosis", "markers", ",", "thiol", "depletion", "and", "cysteine", "protease", "inhibition", "in", "living", "cells", "."]], "ner": [[[7, 7, "Chemical"], [9, 9, "Chemical"], [17, 17, "Chemical"], [19, 19, "Disease"], [22, 22, "Chemical"], [25, 25, "Chemical"]]]}
{"sentences": [["Thus", ",", "CAA", "directly", "reacts", "with", "cellular", "protein", "and", "non", "-", "protein", "thiols", ",", "mediating", "its", "toxicity", "on", "hRPTEC", "."]], "ner": [[[2, 2, "Chemical"], [12, 12, "Chemical"], [16, 16, "Disease"]]]}
{"sentences": [["This", "effect", "can", "be", "reduced", "by", "acidification", "."]], "ner": [[]]}
{"sentences": [["Therefore", ",", "urinary", "acidification", "could", "be", "an", "option", "to", "prevent", "IFO", "nephropathy", "in", "patients", "."]], "ner": [[[10, 11, "Chemical"]]]}
{"sentences": [["Stereological", "methods", "reveal", "the", "robust", "size", "and", "stability", "of", "ectopic", "hilar", "granule", "cells", "after"]], "ner": [[]]}
{"sentences": [["pilocarpine", "-induced", "status", "epilepticus", "in", "the", "adult", "rat", "."]], "ner": [[[0, 0, "Chemical"], [2, 3, "Disease"]]]}
{"sentences": [["Following"]], "ner": [[]]}
{"sentences": [["status", "epilepticus", "in", "the", "rat", ",", "dentate", "granule", "cell", "neurogenesis", "increases", "greatly", ",", "and", "many", "of", "the", "new", "neurons", "appear", "to", "develop", "ectopically", ",", "in", "the", "hilar", "region", "of", "the", "hippocampal", "formation", "."]], "ner": [[[0, 1, "Disease"]]]}
{"sentences": [["It", "has", "been", "suggested", "that", "the", "ectopic", "hilar", "granule", "cells", "could", "contribute", "to", "the", "spontaneous", "seizures", "that", "ultimately", "develop", "after", "status", "epilepticus", "."]], "ner": [[[15, 15, "Disease"], [20, 21, "Disease"]]]}
{"sentences": [["However", ",", "the", "population", "has", "never", "been", "quantified", ",", "so", "it", "is", "unclear", "whether", "it", "is", "substantial", "enough", "to", "have", "a", "strong", "influence", "on", "epileptogenesis", "."]], "ner": [[]]}
{"sentences": [["To", "quantify", "this", "population", ",", "the", "total", "number", "of", "ectopic", "hilar", "granule", "cells", "was", "estimated", "using", "unbiased", "stereology", "at", "different", "times", "after", "pilocarpine"]], "ner": [[[22, 22, "Chemical"]]]}
{"sentences": [["-induced", "status", "epilepticus", "."]], "ner": [[[1, 2, "Disease"]]]}
{"sentences": [["The", "number", "of", "hilar", "neurons", "immunoreactive", "for", "Prox-1", ",", "a", "granule", "-", "cell", "-", "specific", "marker", ",", "was", "estimated", "using", "the", "optical", "fractionator", "method", "."]], "ner": [[]]}
{"sentences": [["The", "results", "indicate", "that", "the", "size", "of", "the", "hilar", "ectopic", "granule", "cell", "population", "after", "status", "epilepticus", "is", "substantial", ",", "and", "stable", "over", "time", "."]], "ner": [[[14, 15, "Disease"]]]}
{"sentences": [["Interestingly", ",", "the", "size", "of", "the", "population", "appears", "to", "be", "correlated", "with", "the", "frequency", "of", "behavioral", "seizures", ",", "because", "animals", "with", "more", "ectopic", "granule", "cells", "in", "the", "hilus", "have", "more", "frequent", "behavioral", "seizures", "."]], "ner": [[[16, 16, "Disease"], [32, 32, "Disease"]]]}
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{"sentences": [["The", "results", "provide", "new", "insight", "into", "the", "potential", "role", "of", "ectopic", "hilar", "granule", "cells", "in", "the", "pilocarpine", "model", "of", "temporal", "lobe", "epilepsy", "."]], "ner": [[[16, 16, "Chemical"], [19, 21, "Disease"]]]}
{"sentences": [["A", "prospective", ",", "open", "-", "label", "trial", "of", "galantamine", "in", "autistic", "disorder", "."]], "ner": [[[8, 8, "Chemical"], [10, 11, "Disease"]]]}
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{"sentences": [["The", "purpose", "of", "this", "study", "was", "to", "assess", "the", "use", "of", "galantamine", ",", "an", "acetylcholinesterase", "inhibitor", "and", "nicotinic", "receptor", "modulator", ",", "in", "the", "treatment", "of", "interfering", "behaviors", "in", "children", "with", "autism", "."]], "ner": [[[11, 11, "Chemical"], [30, 30, "Disease"]]]}
{"sentences": [["METHODS", ":"]], "ner": [[]]}
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{"sentences": [["3.5", "years", ")", "participated", "in", "a", "12-week", ",", "open", "-", "label", "trial", "of", "galantamine", "."]], "ner": [[[13, 13, "Chemical"]]]}
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{"sentences": [["Patients", "showed", "a", "significant", "reduction", "in", "parent", "-", "rated", "irritability", "and", "social", "withdrawal", "on", "the", "ABC", "as", "well", "as", "significant", "improvements", "in", "emotional", "lability", "and", "inattention", "on", "the", "Conners", "'", "Parent", "Rating", "Scale", "--", "Revised", "."]], "ner": [[[9, 9, "Disease"]]]}
{"sentences": [["Similarly", ",", "clinician", "ratings", "showed", "reductions", "in", "the", "anger", "subscale", "of", "the", "Children", "'s", "Psychiatric", "Rating", "Scale", "."]], "ner": [[]]}
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{"sentences": [["Overall", ",", "galantamine", "was", "well", "-", "tolerated", ",", "with", "no", "significant", "adverse", "effects", "apart", "from", "headaches", "in", "one", "patient", "."]], "ner": [[[2, 2, "Chemical"], [15, 15, "Disease"]]]}
{"sentences": [["CONCLUSION", ":"]], "ner": [[]]}
{"sentences": [["In", "this", "open", "trial", ",", "galantamine", "was", "well", "-", "tolerated", "and", "appeared", "to", "be", "beneficial", "for", "the", "treatment", "of", "interfering", "behaviors", "in", "children", "with", "autism", ",", "particularly", "aggression", ",", "behavioral", "dyscontrol", ",", "and", "inattention", "."]], "ner": [[[5, 5, "Chemical"], [24, 24, "Disease"], [27, 27, "Disease"], [29, 30, "Disease"], [33, 33, "Disease"]]]}
{"sentences": [["Further", "controlled", "trials", "are", "warranted", "."]], "ner": [[]]}
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{"sentences": [["The", "authors", "compared", "4-month", "treatment", "outcomes", "for", "olanzapine", "versus", "risperidone", "in", "patients", "with", "first", "-", "episode", "schizophrenia", "spectrum", "disorders", "."]], "ner": [[[7, 7, "Chemical"], [9, 9, "Chemical"], [16, 16, "Disease"]]]}
{"sentences": [["METHOD", ":"]], "ner": [[]]}
{"sentences": [["One", "hundred", "twelve", "subjects", "(", "70", "%", "male", ";", "mean", "age=23.3", "years", "[", "SD", "=", "5.1", "]", ")", "with", "first", "-", "episode", "schizophrenia", "(", "75", "%", ")", ",", "schizophreniform", "disorder", "(", "17", "%", ")", ",", "or", "schizoaffective", "disorder", "(", "8", "%", ")", "were", "randomly", "assigned", "to", "treatment", "with", "olanzapine"]], "ner": [[[22, 22, "Disease"], [28, 29, "Disease"], [36, 37, "Disease"], [48, 48, "Chemical"]]]}
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{"sentences": [["(", "43.7", "%", ",", "95", "%", "CI=28.8%-58.6", "%", ")", "and", "risperidone", "(", "54.3", "%", ",", "95", "%", "CI=39.9%-68.7", "%", ")", "."]], "ner": [[[10, 10, "Chemical"]]]}
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{"sentences": [["Negative", "symptom", "outcomes", "and", "measures", "of", "parkinsonism", "and", "akathisia", "did", "not", "differ", "between", "medications", "."]], "ner": [[[6, 6, "Disease"], [8, 8, "Disease"]]]}
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{"sentences": [["olanzapine", "."]], "ner": [[[0, 0, "Chemical"]]]}
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{"sentences": [["Olanzapine", "may", "have", "an", "advantage", "for", "motor", "side", "effects", "."]], "ner": [[[0, 0, "Chemical"]]]}
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{"sentences": [["Early", "paracentral"]], "ner": [[]]}
{"sentences": [["visual", "field", "loss", "in", "patients", "taking", "hydroxychloroquine", "."]], "ner": [[[0, 2, "Disease"], [6, 6, "Chemical"]]]}
{"sentences": [["OBJECTIVE", ":"]], "ner": [[]]}
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{"sentences": [["DESIGN", ":"]], "ner": [[]]}
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